In vitro characterization of naturally occurring influenza H3NA- viruses lacking the NA gene segment: toward a new mechanism of viral resistance?
Identifieur interne : 000194 ( France/Analysis ); précédent : 000193; suivant : 000195In vitro characterization of naturally occurring influenza H3NA- viruses lacking the NA gene segment: toward a new mechanism of viral resistance?
Auteurs : V. Moules [France] ; O. Ferraris [France] ; O. Terrier [France] ; Emmanuel Giudice [France] ; M. Yver [France] ; Jean-Paul Rolland [France] ; M. Bouscambert-Duchamp [France] ; C. Bergeron [France] ; M. Ottmann ; E. Fournier [France] ; A. Traversier [France] ; C. Boule ; A. Rivoire ; Y. Lin ; A. Hay ; M. Valette [France] ; R. Marquet [France] ; M. Rosa-Calatrava [France] ; N. Naffakh [France] ; Guy Schoehn [France] ; Daniel Thomas [France] ; B. Lina [France]Source :
- Virology [ 0042-6822 ] ; 2010-09-01.
Abstract
Among a panel of 788 clinical influenza H3N2 isolates, two isolates were characterized by an oseltamivir-resistant phenotype linked to the absence of any detectable NA activity. Here, we established that the two H3NA- isolates lack any detectable full-length NA segment, and one of these could be rescued by reverse genetics in the absence of any NA segment sequence. We found that the absence of NA segment induced a moderate growth defect of the H3NA- viruses as on cultured cells. The glycoproteins density at the surface of H3NA- virions was unchanged as compared to H3N2 virions. The HA protein as well as residues 188 and 617 of the PB1 protein were shown to be strong determinants of the ability of H3NA- viruses to grow in the absence of the NA segment. The significance of these findings about naturally occurring seven-segment influenza A viruses is discussed.
Url:
DOI: 10.1016/j.virol.2010.04.030
Affiliations:
- France
- Alsace (région administrative), Auvergne-Rhône-Alpes, Grand Est, Rhône-Alpes, Région Bretagne
- Grenoble, Lyon, Rennes, Strasbourg
- Université Claude Bernard Lyon 1, Université Grenoble-Alpes, Université de Lyon, Université de Rennes 1, Université de Strasbourg, Université européenne de Bretagne
Links toward previous steps (curation, corpus...)
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- to stream Hal, to step Checkpoint: 000256
- to stream Main, to step Merge: 000D79
- to stream Main, to step Curation: 000D73
- to stream Main, to step Exploration: 000D73
- to stream France, to step Extraction: 000194
Links to Exploration step
Hal:hal-00504751Le document en format XML
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Moules</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-42857" status="OLD"> <idno type="RNSR">200717689B</idno> <orgName>Virologie et Pathologie Humaine</orgName> <orgName type="acronym">VirPath</orgName> <date type="start">2007-01-01</date> <date type="end">2010-12-31</date> <desc> <address> <addrLine>Faculté de Médecine Lyon RTH Laennec 7 rue Guillaume Paradin 69372 LYON CEDEX 08</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-6818" type="direct"></relation> <relation active="#struct-194495" type="direct"></relation> <relation active="#struct-301088" type="indirect"></relation> <relation active="#struct-303623" type="direct"></relation> <relation name="FRE3011" active="#struct-441569" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-6818" type="direct"><org type="institution" xml:id="struct-6818" status="VALID"> <idno type="IdRef">149154992</idno> <orgName>École normale supérieure - Lyon</orgName> <orgName type="acronym">ENS Lyon</orgName> <desc> <address> <addrLine>15 parvis René Descartes - BP 7000 - 69342 Lyon Cedex 07</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.ens-lyon.eu/</ref> </desc> </org></tutelle><tutelle active="#struct-194495" type="direct"><org type="institution" xml:id="struct-194495" status="VALID"> <idno type="IdRef">026402823</idno> <idno type="ISNI">0000000121686185</idno> <orgName>Université Claude Bernard Lyon 1</orgName> <orgName type="acronym">UCBL</orgName> <desc> <address> <addrLine>43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-lyon1.fr/</ref> </desc> <listRelation> <relation active="#struct-301088" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-301088" type="indirect"><org type="regroupinstitution" xml:id="struct-301088" status="VALID"> <orgName>Université de Lyon</orgName> <desc> <address> <addrLine>92 rue Pasteur - CS 30122, 69361 Lyon Cedex 07</addrLine> <country key="FR"></country> </address> <ref type="url">https://www.universite-lyon.fr/</ref> </desc> </org></tutelle><tutelle active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc> </org></tutelle><tutelle name="FRE3011" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno> <idno type="ISNI">0000000122597504</idno> <orgName>Centre National de la Recherche Scientifique</orgName> <orgName type="acronym">CNRS</orgName> <date type="start">1939-10-19</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.cnrs.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country><placeName><settlement type="city">Lyon</settlement><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName><orgName type="university">Université Claude Bernard Lyon 1</orgName><orgName type="institution" wicri:auto="newGroup">Université de Lyon</orgName></affiliation></author><author><name sortKey="Ferraris, O" sort="Ferraris, O" uniqKey="Ferraris O" first="O." last="Ferraris">O. 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38058 Grenoble cedex</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-grenoble-alpes.fr</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country><placeName><settlement type="city">Grenoble</settlement><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName><orgName type="university">Université Grenoble-Alpes</orgName></affiliation></author><author><name sortKey="Thomas, Daniel" sort="Thomas, Daniel" uniqKey="Thomas D" first="Daniel" last="Thomas">Daniel Thomas</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-804" status="OLD"> <orgName>Interactions cellulaires et moléculaires</orgName> <orgName type="acronym">ICM</orgName> <date type="start">2000-01-01</date> <date type="end">2007-12-31</date> <desc> <address> <addrLine>Campus de Beaulieu, 263 avenue du Général Leclerc CS 74205 35042 RENNES CEDEX</addrLine> <country key="FR"></country> </address> <ref type="url">http://umr6026.univ-rennes1.fr</ref> </desc> <listRelation> <relation name="UMR6026" active="#struct-441569" type="direct"></relation> <relation active="#struct-300972" type="direct"></relation> <relation active="#struct-105160" type="direct"></relation> <relation active="#struct-528860" type="indirect"></relation> </listRelation> <tutelles><tutelle name="UMR6026" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno> <idno type="ISNI">0000000122597504</idno> <orgName>Centre National de la Recherche Scientifique</orgName> <orgName type="acronym">CNRS</orgName> <date type="start">1939-10-19</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.cnrs.fr/</ref> </desc> </org></tutelle><tutelle active="#struct-300972" type="direct"><org type="institution" xml:id="struct-300972" status="VALID"> <orgName>IFR140</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-105160" type="direct"><org type="institution" xml:id="struct-105160" status="VALID"> <orgName>Université de Rennes 1</orgName> <orgName type="acronym">UR1</orgName> <desc> <address> <addrLine>2 rue du Thabor - CS 46510 - 35065 Rennes cedex</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-rennes1.fr/</ref> </desc> <listRelation> <relation active="#struct-528860" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-528860" type="indirect"><org type="regroupinstitution" xml:id="struct-528860" status="VALID"> <orgName>Université de Rennes</orgName> <orgName type="acronym">UNIV-RENNES</orgName> <date type="start">2018-01-01</date> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country><placeName><settlement type="city">Rennes</settlement><region type="region" nuts="2">Région Bretagne</region></placeName><orgName type="university">Université de Rennes 1</orgName><orgName type="institution" wicri:auto="newGroup">Université européenne de Bretagne</orgName></affiliation></author><author><name sortKey="Lina, B" sort="Lina, B" uniqKey="Lina B" first="B." last="Lina">B. Lina</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-42857" status="OLD"> <idno type="RNSR">200717689B</idno> <orgName>Virologie et Pathologie Humaine</orgName> <orgName type="acronym">VirPath</orgName> <date type="start">2007-01-01</date> <date type="end">2010-12-31</date> <desc> <address> <addrLine>Faculté de Médecine Lyon RTH Laennec 7 rue Guillaume Paradin 69372 LYON CEDEX 08</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-6818" type="direct"></relation> <relation active="#struct-194495" type="direct"></relation> <relation active="#struct-301088" type="indirect"></relation> <relation active="#struct-303623" type="direct"></relation> <relation name="FRE3011" active="#struct-441569" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-6818" type="direct"><org type="institution" xml:id="struct-6818" status="VALID"> <idno type="IdRef">149154992</idno> <orgName>École normale supérieure - Lyon</orgName> <orgName type="acronym">ENS Lyon</orgName> <desc> <address> <addrLine>15 parvis René Descartes - BP 7000 - 69342 Lyon Cedex 07</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.ens-lyon.eu/</ref> </desc> </org></tutelle><tutelle active="#struct-194495" type="direct"><org type="institution" xml:id="struct-194495" status="VALID"> <idno type="IdRef">026402823</idno> <idno type="ISNI">0000000121686185</idno> <orgName>Université Claude Bernard Lyon 1</orgName> <orgName type="acronym">UCBL</orgName> <desc> <address> <addrLine>43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-lyon1.fr/</ref> </desc> <listRelation> <relation active="#struct-301088" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-301088" type="indirect"><org type="regroupinstitution" xml:id="struct-301088" status="VALID"> <orgName>Université de Lyon</orgName> <desc> <address> <addrLine>92 rue Pasteur - CS 30122, 69361 Lyon Cedex 07</addrLine> <country key="FR"></country> </address> <ref type="url">https://www.universite-lyon.fr/</ref> </desc> </org></tutelle><tutelle active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc> </org></tutelle><tutelle name="FRE3011" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno> <idno type="ISNI">0000000122597504</idno> <orgName>Centre National de la Recherche Scientifique</orgName> <orgName type="acronym">CNRS</orgName> <date type="start">1939-10-19</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.cnrs.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country><placeName><settlement type="city">Lyon</settlement><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName><orgName type="university">Université Claude Bernard Lyon 1</orgName><orgName type="institution" wicri:auto="newGroup">Université de Lyon</orgName></affiliation></author></analytic><idno type="DOI">10.1016/j.virol.2010.04.030</idno><series><title level="j">Virology</title><idno type="ISSN">0042-6822</idno><imprint><date type="datePub">2010-09-01</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="mix" xml:lang="it"><term>Orthomyxoviridae</term><term>cryo-EM</term><term>hemagglutinin</term><term>influenza</term><term>neuraminidase</term><term>viral resistance</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"> <p>Among a panel of 788 clinical influenza H3N2 isolates, two isolates were characterized by an oseltamivir-resistant phenotype linked to the absence of any detectable NA activity. Here, we established that the two H3NA- isolates lack any detectable full-length NA segment, and one of these could be rescued by reverse genetics in the absence of any NA segment sequence. We found that the absence of NA segment induced a moderate growth defect of the H3NA- viruses as on cultured cells. The glycoproteins density at the surface of H3NA- virions was unchanged as compared to H3N2 virions. The HA protein as well as residues 188 and 617 of the PB1 protein were shown to be strong determinants of the ability of H3NA- viruses to grow in the absence of the NA segment. The significance of these findings about naturally occurring seven-segment influenza A viruses is discussed.</p> </div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Alsace (région administrative)</li><li>Auvergne-Rhône-Alpes</li><li>Grand Est</li><li>Rhône-Alpes</li><li>Région Bretagne</li></region><settlement><li>Grenoble</li><li>Lyon</li><li>Rennes</li><li>Strasbourg</li></settlement><orgName><li>Université Claude Bernard Lyon 1</li><li>Université Grenoble-Alpes</li><li>Université de Lyon</li><li>Université de Rennes 1</li><li>Université de Strasbourg</li><li>Université européenne de Bretagne</li></orgName></list><tree><noCountry><name sortKey="Boule, C" sort="Boule, C" uniqKey="Boule C" first="C." last="Boule">C. Boule</name><name sortKey="Hay, A" sort="Hay, A" uniqKey="Hay A" first="A." last="Hay">A. Hay</name><name sortKey="Lin, Y" sort="Lin, Y" uniqKey="Lin Y" first="Y." last="Lin">Y. Lin</name><name sortKey="Ottmann, M" sort="Ottmann, M" uniqKey="Ottmann M" first="M." last="Ottmann">M. Ottmann</name><name sortKey="Rivoire, A" sort="Rivoire, A" uniqKey="Rivoire A" first="A." last="Rivoire">A. Rivoire</name></noCountry><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Moules, V" sort="Moules, V" uniqKey="Moules V" first="V." last="Moules">V. Moules</name></region><name sortKey="Bergeron, C" sort="Bergeron, C" uniqKey="Bergeron C" first="C." last="Bergeron">C. Bergeron</name><name sortKey="Bouscambert Duchamp, M" sort="Bouscambert Duchamp, M" uniqKey="Bouscambert Duchamp M" first="M." last="Bouscambert-Duchamp">M. Bouscambert-Duchamp</name><name sortKey="Ferraris, O" sort="Ferraris, O" uniqKey="Ferraris O" first="O." last="Ferraris">O. Ferraris</name><name sortKey="Fournier, E" sort="Fournier, E" uniqKey="Fournier E" first="E." last="Fournier">E. Fournier</name><name sortKey="Giudice, Emmanuel" sort="Giudice, Emmanuel" uniqKey="Giudice E" first="Emmanuel" last="Giudice">Emmanuel Giudice</name><name sortKey="Lina, B" sort="Lina, B" uniqKey="Lina B" first="B." last="Lina">B. Lina</name><name sortKey="Marquet, R" sort="Marquet, R" uniqKey="Marquet R" first="R." last="Marquet">R. Marquet</name><name sortKey="Naffakh, N" sort="Naffakh, N" uniqKey="Naffakh N" first="N." last="Naffakh">N. Naffakh</name><name sortKey="Rolland, Jean Paul" sort="Rolland, Jean Paul" uniqKey="Rolland J" first="Jean-Paul" last="Rolland">Jean-Paul Rolland</name><name sortKey="Rosa Calatrava, M" sort="Rosa Calatrava, M" uniqKey="Rosa Calatrava M" first="M." last="Rosa-Calatrava">M. Rosa-Calatrava</name><name sortKey="Schoehn, Guy" sort="Schoehn, Guy" uniqKey="Schoehn G" first="Guy" last="Schoehn">Guy Schoehn</name><name sortKey="Terrier, O" sort="Terrier, O" uniqKey="Terrier O" first="O." last="Terrier">O. Terrier</name><name sortKey="Thomas, Daniel" sort="Thomas, Daniel" uniqKey="Thomas D" first="Daniel" last="Thomas">Daniel Thomas</name><name sortKey="Traversier, A" sort="Traversier, A" uniqKey="Traversier A" first="A." last="Traversier">A. Traversier</name><name sortKey="Valette, M" sort="Valette, M" uniqKey="Valette M" first="M." last="Valette">M. Valette</name><name sortKey="Yver, M" sort="Yver, M" uniqKey="Yver M" first="M." last="Yver">M. Yver</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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